WHAT MAKES A GREAT DIGITAL MICROSCOPE IMAGE?

It's not just snapping a photo

Sometimes the transition switch from conventional microscopy to digital pathology is made challenging for the pathologist by differences in what the viewed images look like over the two mediums. So, what do you do to make a great digital microscope image?

IT ALL STARTS WITH A HIGH-QUALITY IMAGE

No amount of processing can make up for a less than great raw image, the material must be of very high quality. A high-quality imaging system with a well-integrated objective lens and components make a great starting point, but what really makes a difference is how the number of adjacent photographs of the sample on the glass slide are captured and processed.

What makes the Grundium Ocus® microscope slide scanner special is that it doesn’t just filter colors from a regular image, but instead red, green, and blue are all photographed individually in full resolution. This ensures a far superior, true color reproduction instead of the common approximation. Different staining techniques appear natural as if viewed on a microscope and make for easy collaboration and analysis of scans between experts.

IMAGE PROCESSING FOR BEST RESULTS

If you’re capturing images of samples with varying thickness, such as tissue, at a constant distance, some parts of the sample may be out of focus. To mitigate this the Ocus has electronic autofocus. As it captures images, it is constantly following the sharpness, predicting the elevation from the adjacent squares. If the image isn’t sharp, the Ocus automatically expands the focus search range to return to focus. The focus is built in a dynamic and adaptive way, which adapts to slide tilt and sample topography, adding to the clarity of the scanned image.

The Ocus has an artificial intelligence algorithm, which detects potentially interesting areas in the overview image. When the user selects their area of interest the Ocus uses the detected sample regions in the overview image to guide scanning and focusing. This is yet another way the Ocus works smart to make the work of the pathologist faster, easier, and more convenient.

STITCHING DONE RIGHT

A microscope scanner basically divides the scanning area into a grid, and then takes a high-resolution image of each part. A viewable image is then stitched together from those individual photos. Because there is always minute overlap at the seams between photos, they are “stitched” together digitally. If each photo is matched to the next linearly it can result in inaccuracies with rows of photos skewing off and not matching at their ends. The Ocus uses a patented Grundium stitching model known as Global Optimization where every photo is matched to all other photos in the entire scan area, not just the previous. This results in a highly accurate, undistorted image like no other!

CALIBRATION TO HIGH QUALITY STANDARDS

Each Grundium Ocus® scanner is tested to the highest standard before it is shipped to a customer. In calibration each scanner is adjusted for variations in lens distortion, shading, focus correction, image magnification, stage movement, camera alignment and LED luminosity, and adjusted accordingly. This ensures every single scanner leaves the assembly line up to a tight specification.

DESIGNING AND MANUFACTURING A HIGH-PRECISION INSTRUMENT

The Grundium team has its roots in Nokia mobile devices. This background gives us a unique edge in designing beautiful, robust, compact, and practical high-precision optical instruments, and manufacture them to a rigorous quality specification. Grundium employs experts in many different disciplines. In addition to all the know-how that goes into manufacturing the devices, especially important for making state-of-the-art digital scanners are optics, signal processing and mathematical optimization. All this expertise combined enables us to look outside the box and create solutions which are smaller, cleverer, and more practical than anything else.

IMAGING MADE PRACTICAL

The Grundium Ocus® is the most practical microscope scanner in the world. Its small footprint means it can find a spot in any lab. The Ocus® is so simple to use anybody can be trained to operate it in just 15 minutes. Created by ex-Nokia flagship camera phone engineers, it takes the sharpest images in the business. It is much more affordable than big multislide scanners. Its software is so advanced it can be integrated with any existing LIS and it supports the most common file formats. The Ocus scanners simply remove the entry barrier to digital pathology.

If you are looking for a small footprint and sharp imaging component for your pathology solution or if you want to hear more about how to integrate an Ocus scanner into your system, please contact us.

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About Grundium

A global leader in advanced imaging technology, Grundium makes digital pathology and best professional diagnosis available for all life – whether human, animal, plant or other. This is achieved by doing something that nobody else can: applying state-of-the-art mobile technology in digital pathology. Established in 2015 by ex-Nokia engineers, the Tampere-based company is democratizing digital pathology with the Ocus® microscope scanners. The cutting-edge imaging solutions are based on over 20 years of experience in optics, sensors and beautiful high-precision devices. Grundium serves various industries and businesses enhancing quality and processes, protecting human life and safeguarding a clean environment.
Quotes
Not only has Grundium created something unique in the market with your beautifully designed small-footprint scanner, but you also have a super technical team that can work really close together to make the whole solution seamless and is willing to invest themselves in making something new. It’s super unique in the world to have everything from the region of interest, focus layers, depth of field and the whole experience totally integrated.
— Ben Cahoon
Techcyte Inc. 
CEO

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See the OCUS® portable digital microscope scanner in action – request your free personal online live demo now. A Grundium expert will contact you personally to schedule a suitable 30-minute demo time for you. In the demo we will answer all your questions about which Ocus® scanner fits your needs best, we will talk pricing, share stories about how others are using the scanners, and help you fast forward the digital pathology experience in your lab.

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