Scientific Insights: Exploring Research Powered by Ocus Scanners

Dive into the world of scientific discovery where Ocus scanners play a pivotal role in advancing knowledge across various fields. Our collection of research articles showcases the innovative applications and impactful studies conducted using Ocus scanners.From groundbreaking medical research to cutting-edge scientific inquiries, these publications highlight how our technology is contributing to critical advancements and insights.

Explore the depth and breadth of research facilitated by Ocus scanners, reflecting our commitment to supporting the scientific community in their quest for understanding and innovation.

Digital pathology and telemedicine

Telepathology and remote diagnosis

Kaushal, R. K., Yadav, S., Sahay, A., Karnik, N., Agrawal, T., Dave, V., Singh, N., Shah, A., & Desai, S. B. (2023).

Validation of Remote Digital Pathology based diagnostic reporting of Frozen Sections from home. 

Journal of pathology informatics, 14, 100312.
https://doi.org/10.1016/j.jpi.2023.100312

 

Silas, O. A., Abdulkareem, F., Novo, J. E., Zheng, Y., Nannini, D. R., Gursel, D. B., Anorlu, R., Musa, J., Wehbe, F. H., Sagay, A. S., Ogunsola, F. T., Murphy, R. L., Hou, L., & Wei, J. J. (2022).

Telepathology in Nigeria for Global Health Collaboration. 

Annals of global health, 88(1), 81.
https://doi.org/10.5334/aogh.3673

 

Kaushal, R. K., Rajaganesan, S., Rao, V., Sali, A., More, B., & Desai, S. B. (2021).

Validation of a Portable Whole-Slide Imaging System for Frozen Section Diagnosis.

Journal of pathology informatics, 12, 33.
https://doi.org/10.4103/jpi.jpi_95_20

 

Stegmüller, T., Abbet, C., Bozorgtabar, B., Clarke, H., Petignat, P., Vassilakos, P., & Thiran, J. (2023).

Self-supervised learning-based cervical cytology for the triage of HPV-positive women in resource-limited settings and low-data regime.
ArXiv.
https://doi.org/10.48550/arXiv.2302.05195

 

Vassilakos, P., Clarke, H., Murtas, M., Stegmüller, T., Wisniak, A., Akhoundova, F., Sando, Z., Orock, G. E., Sormani, J., Thiran, J. P., & Petignat, P. (2023).

Telecytologic diagnosis of cervical smears for triage of self-sampled human papillomavirus-positive women in a resource-limited setting: concept development before implementation.

Journal of the American Society of Cytopathology, 12(3), 170–180.
https://doi.org/10.1016/j.jasc.2023.02.001

 

Holmström, O., Linder, N., Kaingu, H. et al.

Point-of-Care Digital Cytology With Artificial Intelligence for Cervical Cancer Screening in a Resource-Limited Setting.

JAMA Netw Open., 2021;4(3):e211740.
https://doi.org/10.1001/jamanetworkopen.2021.1740

 

Gruber-Mösenbacher, U., Katzell, L., McNeely, M., Neier, E., Jean, B., Kuran, A., & Chamala, S. (2021).

Digital Pathology in Cameroon.

JCO global oncology, 7, 1380–1389.
https://doi.org/10.1200/GO.21.00166

Cellular and molecular biology

Zhang, Q., Fei, L., Han, R., Huang, R., Wang, Y., Chen, H., Yao, B., Qiao, N., Wang, Z., Ma, Z., Ye, Z., Zhang, Y., Wang, W., Wang, Y., Kong, L., Shou, X., Cao, X., Zhou, X., Shen, M., Cheng, H., … Zhao, Y. (2022).

Single-cell transcriptome reveals cellular hierarchies and guides p-EMT-targeted trial in skull base chordoma. 

Cell discovery, 8(1), 94.
https://doi.org/10.1038/s41421-022-00459-2

 

Zhang, Q., Yao, B., Long, X., Chen, Z., He, M., Wu, Y., Qiao, N., Ma, Z., Ye, Z., Zhang, Y., Yao, S., Wang, Y., Cheng, H., Chen, H., Ye, H., Wang, Y., Li, Y., Chen, J., Zhang, Z., Guo, F., … Zhao, Y. (2023).

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET. 

Cell reports. Medicine, 4(2), 100934.
https://doi.org/10.1016/j.xcrm.2023.100934

 

Salzmann, M., Platzer, H., Mussbacher, M., Derler, M., Lenz, M., Haider, P., Brekalo, M., Kral-Pointner, J. B., Kastl, S., Speidl, W. S., Preissner, K. T., Schubert, U., Bischoff, M., Uhrin, P., Wojta, J., & Hohensinner, P. J. (2023).

Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions. 

Biochimica et biophysica acta. Molecular basis of disease, 1869(3), 166616.
https://doi.org/10.1016/j.bbadis.2022.166616

 

Dwivedi, N., Mazumder, T., Veeraraghavan, G., Siva, R., PK, S., Ranade, R., ... & Dhar, S. K. (2023).

In vitro and in vivo evidences propound therapeutic potential of Lipocalin 2 in cervical carcinoma. 

bioRxiv, 2023-01.
https://doi.org/10.1101/2023.01.13.523914

 

Yang, H., Sun, B., Fan, L., Ma, W., Xu, K., Hall, S. R. R., Wang, Z., Schmid, R. A., Peng, R. W., Marti, T. M., Gao, W., Xu, J., Yang, W., & Yao, F. (2022).

Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma.

Theranostics, 12(7), 3104–3130.
https://doi.org/10.7150/thno.69590

Su, W., Wu, S., Yang, Y. et al.

Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice. 

Nat Commun 13, 6577 (2022).
https://doi.org/10.1038/s41467-022-34299-1

 

Binothman, N., Aljadani, M., Alghanem, B., Refai, M. Y., Rashid, M., Al Tuwaijri, A., Alsubhi, N. H., Alrefaei, G. I., Khan, M. Y., Sonbul, S. N., Aljoud, F., Alhayyani, S., Abdulal, R. H., Ganash, M., & Hashem, A. M. (2023).

Identification of novel interacts partners of ADAR1 enzyme mediating the oncogenic process in aggressive breast cancer. 

Scientific reports, 13(1), 8341.
https://doi.org/10.1038/s41598-023-35517-6

 

Guo, Q., Xiao, X., & Zhang, J. (2021).

MYD88 Is a Potential Prognostic Gene and Immune Signature of Tumor Microenvironment for Gliomas.

Frontiers in oncology, 11, 654388.
https://doi.org/10.3389/fonc.2021.654388

 

Ma, J., Xiong, F., Li, Z., Dong, G., Sun, X., Yin, W., & Cai, H. (2023).

The effect of chronic alcohol exposure on spatial memory and BDNF-TrkB- PLCγ1 signaling in the hippocampus of male and female mice. 

Heliyon, 9(6), e16660.
https://doi.org/10.1016/j.heliyon.2023.e16660

Pathophysiology & clinical conditions

Cai, H., Xiao, Y., Chen, S., Lu, Y., Du, J., You, Y., Zhu, J., Zhou, J., Cai, W., & Wang, Y. (2023).

Heterozygous Actg2R257C mice mimic the phenotype of megacystis microcolon intestinal hypoperistalsis syndrome.

Neurogastroenterology and motility, 35(1), e14472.
https://doi.org/10.1111/nmo.14472

 

Morozov, D., Parvin, N., Conaway, M., Oxley, G., Baldelomar, E. J., Cwiek, A., deRonde, K., Beeman, S. C., Charlton, J. R., & Bennett, K. M. (2022).

Estimating Nephron Number from Biopsies: Impact on Clinical Studies. 

Journal of the American Society of Nephrology : JASN, 33(1), 39–48.
https://doi.org/10.1681/ASN.2021070998

 

Ceausu, A. R., Ciolofan, A., Blidisel, A., Cosma, A. A., Gaje, P. N., & Cretu, O. (2023).

Chloride Intracellular Channel Protein 1 Expression and Angiogenic Profile of Liver Metastasis of Digestive Origin. 

Current issues in molecular biology, 45(2), 1396–1406.
https://doi.org/10.3390/cimb45020091

 

Barb, A. C., Pasca Fenesan, M., Pirtea, M., Margan, M. M., Tomescu, L., Melnic, E., & Cimpean, A. M. (2023).

Tertiary Lymphoid Structures (TLSs) and Stromal Blood Vessels Have Significant and Heterogeneous Impact on Recurrence, Lymphovascular and Perineural Invasion amongst Breast Cancer Molecular Subtypes. 

Cells, 12(8), 1176.
https://doi.org/10.3390/cells12081176

 

Gatto, R. G., Carlos, A. F., Reichard, R. R., Lowe, V. J., Whitwell, J. L., & Josephs, K. A. (2023).

Comparative assessment of regional tau distribution by Tau-PET and Post-mortem neuropathology in a representative set of Alzheimer's & frontotemporal lobar degeneration patients. 

PloS one, 18(5), e0284182.
https://doi.org/10.1371/journal.pone.0284182

Stålhammar, G., Gill, V.T.

Digital morphometry and cluster analysis identifies four types of melanocyte during uveal melanoma progression.

Commun Med 3, 60 (2023).
https://doi.org/10.1038/s43856-023-00291-z

 

Herrspiegel, C., Plastino, F., Lardner, E., Seregard, S., Williams, P. A., André, H., & Stålhammar, G. (2023).

A serum protein signature at the time of Uveal Melanoma diagnosis predicts long-term patient survival. 

BMC cancer, 23(1), 277.
https://doi.org/10.1186/s12885-023-10757-x

 

Boia, E. R., Boia, S., Ceausu, R. A., Gaje, P. N., Maaroufi, S. M., Sandru, F., & Raica, M. (2023).

The Follicular Dendritic Cells and HPV 18 Interrelation in Head and Neck Squamous Cell Carcinomas of the Larynx. 

Medicina (Kaunas, Lithuania), 59(6), 1072.
https://doi.org/10.3390/medicina59061072

 

Yilmaz, E. N., Albrecht, S., Groll, K., Thomas, C., Wallhorn, L., Herold, M., Hucke, S., Klotz, L., & Kuhlmann, T. (2023).

Influx of T cells into corpus callosum increases axonal injury, but does not change the course of remyelination in toxic demyelination.

Glia, 71(4), 991–1001.
https://doi.org/10.1002/glia.24319

Zhang, F., Zhang, Q., Zhu, J., Yao, B., Ma, C., Qiao, N., He, S., Ye, Z., Wang, Y., Han, R., Feng, J., Wang, Y., Qin, Z., Ma, Z., Li, K., Zhang, Y., Tian, S., Chen, Z., Tan, S., Wu, Y., … Zhao, Y. (2022).

Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors.

Cell research, 32(12), 1047–1067.
https://doi.org/10.1038/s41422-022-00736-5

 

Stegmüller, T., Abbet, C., Bozorgtabar, B., Clarke, H., Petignat, P., Vassilakos, P., & Thiran, J. (2023).

Self-supervised learning-based cervical cytology for the triage of HPV-positive women in resource-limited settings and low-data regime.

ArXiv.
https://doi.org/10.48550/arXiv.2302.05195

 

Jia, Y., Luo, J., Lan, Y., Li, C., Ma, L., Zhu, X., Ruan, F., & Zhou, J. (2021).

Label-free proteomics uncovers SMC1A expression is Down-regulated in AUB-E. 

Reproductive biology and endocrinology : RB&E, 19(1), 35.
https://doi.org/10.1186/s12958-021-00713-4 
Poster at 10082020-023250

 

Cwiek, A., Suzuki, M., deRonde, K., Conaway, M., Bennett, K. M., El Dahr, S., Reidy, K. J., & Charlton, J. R. (2021).

Premature differentiation of nephron progenitor cell and dysregulation of gene pathways critical to kidney development in a model of preterm birth.

Scientific reports, 11(1), 21667.
https://doi.org/10.1038/s41598-021-00489-y

 

Patel, A., Balis, U., Cheng, J., Li, Z., Lujan, G., McClintock, D. S., Pantanowitz, L., & Parwani, A. (2021).

Contemporary Whole Slide Imaging Devices and Their Applications within the Modern Pathology Department: A Selected Hardware Review.

Journal of pathology informatics, 12, 50.
https://doi.org/10.4103/jpi.jpi_66_21

 

Zhang, M., Zhang, H., Fu, M., Zhang, J., Zhang, C., Lv, Y., Fan, F., Zhang, J., Xu, H., Ye, D., Yang, H., Hua, W., & Mao, Y. (2021).

The Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas.

Frontiers in cell and developmental biology, 9, 670145.
https://doi.org/10.3389/fcell.2021.670145

 

Fei, W., Zhao, Y., Wu, X. et al.

Nucleoside transporter-guided cytarabine-conjugated liposomes for intracellular methotrexate delivery and cooperative choriocarcinoma therapy.

J Nanobiotechnol 19, 184 (2021).
https://doi.org/10.1186/s12951-021-00931-3

 

Guo, F., Zheng, X., He, Z., Zhang, R., Zhang, S., Wang, M., Chen, H., & Wang, W. (2021).

Nimodipine Promotes Functional Recovery After Spinal Cord Injury in Rats.

Frontiers in pharmacology, 12, 733420.
https://doi.org/10.3389/fphar.2021.733420

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