Scientific Insights: Exploring Research Powered by Ocus Scanners

Dive into the world of scientific discovery where Ocus scanners play a pivotal role in advancing knowledge across various fields. Our collection of research articles showcases the innovative applications and impactful studies conducted using Ocus scanners.From groundbreaking medical research to cutting-edge scientific inquiries, these publications highlight how our technology is contributing to critical advancements and insights.

Explore the depth and breadth of research facilitated by Ocus scanners, reflecting our commitment to supporting the scientific community in their quest for understanding and innovation.

Telepathology and remote diagnosis

Journal of pathology informatics - 2023 - Open Access

Validation of Remote Digital Pathology based diagnostic reporting of Frozen Sections from home

Remote frozen section diagnosis with high concordance to conventional microscopy.

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Annals of global health - 2022 - Open Access

Telepathology in Nigeria for Global Health Collaboration

Telepathology enables expert slide review and collaborative diagnostics across underserved healthcare regions.

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Journal of pathology informatics - 2021 - Open Access

Validation of a Portable Whole-Slide Imaging System for Frozen Section Diagnosis

Portable slide scanning validated for accurate intraoperative frozen-section diagnostics.

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USCAP Annual Meeting - 2024 - Open Access

Virtual Pathology: A Remote Cytology Experience

Expert cytology assessment delivered remotely during interventional procedures.

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Journal of the American Society of Cytopathology - 2023 - Open Access

Telecytologic diagnosis of cervical smears for triage of self-sampled human papillomavirus-positive women in a resource-limited setting: concept development before implementation.

Remote cytology screening enables same-day triage of HPV-positive samples.

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JAMA Netw Open - 2021 - Open Access

Point-of-Care Digital Cytology With Artificial Intelligence for Cervical Cancer Screening in a Resource-Limited Setting

AI-assisted cell detection supporting reliable screening in resource-limited clinics.

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JCO global oncology - 2021 - Open Access

Digital Pathology in Cameroon

Remote pathology expertise expands cancer diagnostics in hospitals without on-site specialists.

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ArXiv - 2023 - Open Access

Self-supervised learning-based cervical cytology for the triage of HPV-positive women in resource-limited settings and low-data regime

AI learning from unlabeled slides to advance cytology diagnostics in low-resource settings.

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USCAP Annual Meeting - 2024 - Open Access

Evaluation of whole slide imaging for frozen intraoperative consultations at a large academic institution

Whole-slide imaging supports scalable digital workflows for high-volume intraoperative pathology consultations.

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Cellular and molecular biology

Cell discovery - 2022 - Open Access

Single-cell transcriptome reveals cellular hierarchies and guides p-EMT-targeted trial in skull base chordoma.

Single-cell analysis reveals tumor hierarchies and informs targeted therapy strategies.

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Cell reports. Medicine - 2023 - Open Access

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.

Single-cell transcriptomics improves molecular classification and recurrence prediction of pituitary tumors.

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Biochimica et biophysica acta. Molecular basis of disease - 2023 - Open Access

Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions.

Immune cell infiltration in developing atherosclerotic plaques revealed through digital histology imaging.

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bioRxiv - 2023 - Open Access

In vitro and in vivo evidences propound therapeutic potential of Lipocalin 2 in cervical carcinoma.

Histological tumor analysis links Lipocalin-2 inhibition to reduced cervical cancer progression.

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Theranostics - 2022 - Open Access

Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma.

Whole-slide analysis maps THBS2+ fibroblasts driving aggressive lung adenocarcinoma biology.

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Nat Commun - 2022 - Open Access

Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice.

Digital tissue imaging unveils molecular insights into fatty liver disease.

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Scientific reports - 2023 - Open Access

Identification of novel interacts partners of ADAR1 enzyme mediating the oncogenic process in aggressive breast cancer.

Digital slide analysis reveals molecular insights into aggressive breast cancer.

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Frontiers in oncology - 2021 - Open Access

MYD88 Is a Potential Prognostic Gene and Immune Signature of Tumor Microenvironment for Gliomas.

Digital pathology analysis identifies MYD88 as a prognostic immune biomarker in glioma.

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Heliyon - 2023 - Open Access

The effect of chronic alcohol exposure on spatial memory and BDNF-TrkB- PLCγ1 signaling in the hippocampus of male and female mice.

Alcohol-induced hippocampal signaling changes revealed through digital microscopy.

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Pathophysiology & clinical conditions

Neurogastroenterology and motility - 2023 - Open Access

Heterozygous Actg2R257C mice mimic the phenotype of megacystis microcolon intestinal hypoperistalsis syndrome.

Digital histology characterizes gastrointestinal dysfunction driven by Actg2 mutation.

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Journal of the American Society of Nephrology : JASN - 2022 - Open Access

Estimating Nephron Number from Biopsies: Impact on Clinical Studies.

Digital biopsy imaging reveals therapeutic targets in pituitary tumors.

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Current issues in molecular biology - 2023 - Open Access

Chloride Intracellular Channel Protein 1 Expression and Angiogenic Profile of Liver Metastasis of Digestive Origin.

Digital microscopy links CLIC1 expression to angiogenic patterns in liver metastases.

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Cells - 2023 - Open Access

Tertiary Lymphoid Structures (TLSs) and Stromal Blood Vessels Have Significant and Heterogeneous Impact on Recurrence, Lymphovascular and Perineural Invasion amongst Breast Cancer Molecular Subtypes.

Digital slide analysis reveals prognostic role of tertiary lymphoid structures in breast cancer.

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PloS one - 2023 - Open Access

Comparative assessment of regional tau distribution by Tau-PET and Post-mortem neuropathology in a representative set of Alzheimer's & frontotemporal lobar degeneration patients.

Digital neuropathology correlated Tau-PET imaging with regional tau burden in Alzheimer’s disease.

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Commun Med3 - 2023 - Open Access

Digital morphometry and cluster analysis identifies four types of melanocyte during uveal melanoma progression.

Large-scale digital cell analysis maps distinct tumor cell populations in uveal melanoma.

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BMC cancer - 2023 - Open Access

A serum protein signature at the time of Uveal Melanoma diagnosis predicts long-term patient survival.

Blood-based biomarker signature stratifies metastatic risk in newly diagnosed uveal melanoma.

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Medicina (Kaunas, Lithuania) - 2023 - Open Access

The Follicular Dendritic Cells and HPV 18 Interrelation in Head and Neck Squamous Cell Carcinomas of the Larynx.

Immune cell patterns linked to HPV-18 in laryngeal carcinoma identified with digital pathology.

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Glia - 2023 - Open Access

Influx of T cells into corpus callosum increases axonal injury, but does not change the course of remyelination in toxic demyelination.

Axonal damage linked to T-cell infiltration in demyelination through digital pathology.

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Cell research - 2022 - Open Access

Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors.

Proteogenomic mapping across tumor subtypes reveals new therapeutic targets in PitNET.

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ArXiv - 2023 - Open Access

Self-supervised learning-based cervical cytology for the triage of HPV-positive women in resource-limited settings and low-data regime.

AI trained on unlabeled slides advances scalable cervical screening diagnostics.

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Reproductive biology and endocrinology : RB&E - 2021 - Open Access

Label-free proteomics uncovers SMC1A expression is Down-regulated in AUB-E.

Reduced SMC1A expression in abnormal uterine bleeding revealed by proteomics and digital pathology.

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Scientific reports - 2021 - Open Access

Premature differentiation of nephron progenitor cell and dysregulation of gene pathways critical to kidney development in a model of preterm birth.

Digital kidney histology unveils disrupted developmental pathways associated with preterm birth.

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Journal of pathology informatics - 2021 - Open Access

Contemporary Whole Slide Imaging Devices and Their Applications within the Modern Pathology Department: A Selected Hardware Review.

WSI hardware review highlights portable and high-throughput scanners for modern pathology.

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Frontiers in cell and developmental biology - 2021 - Open Access

The Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas.

Digital histology links IDH mutations to suppressed B7H3 and VEGFA signaling in gliomas.

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J Nanobiotechnol 19 - 2021 - Open Access

Nucleoside transporter-guided cytarabine-conjugated liposomes for intracellular methotrexate delivery and cooperative choriocarcinoma therapy.

Digital slide imaging enabling histological evaluation of targeted nanotherapy in choriocarcinoma.

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Frontiers in pharmacology - 2021 - Open Access

Nimodipine Promotes Functional Recovery After Spinal Cord Injury in Rats.

Digital histology shows improved tissue preservation following spinal cord injury treatment.

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